| Benign Melanocytic Lesions Pathologymindmap.com |
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Melanocytic lesions
Benign lesions
General Features
Symmetric
Absence or rare nuclear atypia
(except Spitz nevus)
No Pagetoid spread
(except Spitz nevus)
Neurotization
No “shoulder” of melanocytic hyperplasia
Downward maturation of Nevus cells
Blue Nevus
Intradermal nevus
Spindled cells with Melanophages
large amount of pigment
Grenz zone
DDx:
DF (hemosiderin pigment instead)
Spitz Nevus (low or absent melanin)
Dysplastic Nevus
Compound Nevus
Nests @ junction and w/in dermis
Downward maturation of melanocytes
Other benign features (see general features section above)
Congenital melanocytic nevus
Mainly Newborns
General benign features
Nevus cells in deep dermis
Nevus cells around follicular structures
Intradermal Nevus
Nests in dermis only
Downward maturation of melanocytes
Other benign features (see general features section above)
Junctional Nevus
Nests @ epidermis-dermis junction
Downward maturation of melanocytes
Other benign features (see general features section above)
Spitz Nevus
Marked atypia
Mitotic
Pagetoid spread (may be seen)
Melanin is low or absent
Architecture is
Symmetric
Triangular
Fascicles perpendicular to epidermis
Downward maturation of Nevus cells
May be vascular
DDx: Malignant Melanoma and Hemangioma
Benign lesions
General Features
Symmetric
Absence or rare nuclear atypia
(except Spitz nevus)
No Pagetoid spread
(except Spitz nevus)
Neurotization
No “shoulder” of melanocytic hyperplasia
Downward maturation of Nevus cells
Blue Nevus
Intradermal nevus
Spindled cells with Melanophages
large amount of pigment
Grenz zone
DDx:
DF (hemosiderin pigment instead)
Spitz Nevus (low or absent melanin)
Dysplastic Nevus
Compound Nevus
Nests @ junction and w/in dermis
Downward maturation of melanocytes
Other benign features (see general features section above)
Congenital melanocytic nevus
Mainly Newborns
General benign features
Nevus cells in deep dermis
Nevus cells around follicular structures
Intradermal Nevus
Nests in dermis only
Downward maturation of melanocytes
Other benign features (see general features section above)
Junctional Nevus
Nests @ epidermis-dermis junction
Downward maturation of melanocytes
Other benign features (see general features section above)
Spitz Nevus
Marked atypia
Mitotic
Pagetoid spread (may be seen)
Melanin is low or absent
Architecture is
Symmetric
Triangular
Fascicles perpendicular to epidermis
Downward maturation of Nevus cells
May be vascular
DDx: Malignant Melanoma and Hemangioma