| Cytology (Normal / Reactive Gyn) Pathologymindmap.com |
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Atrophic vaginal smear
Postpartum or postmenopause
Mostly Parabasal and basal cells
w/ Autolytic features
“blue blobs”
pyknotic parabasal cells w/ eosinophilic cytoplasm
“mummified cells”
Chronic follicular cervicitis
Small and large lymphocytes
Plasma cells
Tangible body macrophages
Endocervical cells
Well defined borders
Honey combing, picket fence or columnar cells
Small Nucleoli
Endometrial glandular cells
3D blue cell balls
round to ovalnuclei
scant basophilic cytoplasm
Immature metaplastic
Parabasal in size
Basophilic cytoplasm
“cookie cutter” shape
Mature cycling female Vaginal smear
Generally “No Parabasal” cells
2 cell types
Superficial
Intermediate
Microglandular hyperplasia
AKA Birth control pill changes or pseudoparakeratosis
? assoc. w/ Arias Stella reaction (Endometrial decidualization)
hypechromasia and large eccentric nuclei
may be assoc. w/ entopic pregnancy
Navicular cells
Progesterone effect
Boat shaped
Glycogenated Cells
DDx
Koilocytes
Parabasal cells in sheets or vaginal smear
Hypo-Estrogen
e.g. Turner’s Syndrome
Perimenarche Vaginal smear
The 3 cell types
Superficial
Intermediate
Parabasal
Pollen
Transparent oval structures
Refractile glassy capsule
Thick cell wall w/ spikes
Post menopausal vaginal smear
Generally “No superficial” cells
Exceptions
On Estrogen
Assoc. w/ certain malignancies
Endometrial Adeno CA
Granulosa-Theca cell tumors
Radiation changes
Cytomegaly
Proportionate karyomegaly
Normal N/C ratio
Hypochromatic nucleus
Cytoplasmic vacuoles
Sometimes multinucleated
Superficial cell Predominance of vaginal smear
Estrogen Effect
Transformation Zone
Squamo-columnar junction
Vaginal Adenosis
Gland free Squamous lined vagina w/
Ectopic glandular Cells or
Squamous metaplasia
Assoc. w/ DES
Postpartum or postmenopause
Mostly Parabasal and basal cells
w/ Autolytic features
“blue blobs”
pyknotic parabasal cells w/ eosinophilic cytoplasm
“mummified cells”
Chronic follicular cervicitis
Small and large lymphocytes
Plasma cells
Tangible body macrophages
Endocervical cells
Well defined borders
Honey combing, picket fence or columnar cells
Small Nucleoli
Endometrial glandular cells
3D blue cell balls
round to ovalnuclei
scant basophilic cytoplasm
Immature metaplastic
Parabasal in size
Basophilic cytoplasm
“cookie cutter” shape
Mature cycling female Vaginal smear
Generally “No Parabasal” cells
2 cell types
Superficial
Intermediate
Microglandular hyperplasia
AKA Birth control pill changes or pseudoparakeratosis
? assoc. w/ Arias Stella reaction (Endometrial decidualization)
hypechromasia and large eccentric nuclei
may be assoc. w/ entopic pregnancy
Navicular cells
Progesterone effect
Boat shaped
Glycogenated Cells
DDx
Koilocytes
Parabasal cells in sheets or vaginal smear
Hypo-Estrogen
e.g. Turner’s Syndrome
Perimenarche Vaginal smear
The 3 cell types
Superficial
Intermediate
Parabasal
Pollen
Transparent oval structures
Refractile glassy capsule
Thick cell wall w/ spikes
Post menopausal vaginal smear
Generally “No superficial” cells
Exceptions
On Estrogen
Assoc. w/ certain malignancies
Endometrial Adeno CA
Granulosa-Theca cell tumors
Radiation changes
Cytomegaly
Proportionate karyomegaly
Normal N/C ratio
Hypochromatic nucleus
Cytoplasmic vacuoles
Sometimes multinucleated
Superficial cell Predominance of vaginal smear
Estrogen Effect
Transformation Zone
Squamo-columnar junction
Vaginal Adenosis
Gland free Squamous lined vagina w/
Ectopic glandular Cells or
Squamous metaplasia
Assoc. w/ DES