Cytology (Neoplastic Gyn)
Pathologymindmap.com
Atypical Squamous cells of Undetermined Significance (ASC-US)
       Increase size in squamous cells (2-3x normal intermediate cell nucleus)
       Hypo or normochromatic
       May be HPV related
Endocervical Adeno CA
       Palisading arrangement
       Overlapping nuclei
       Irregular chromatin
       Columnar cells
       Eosinophilic cytoplasm
       DDx
               Endometrial Adeno CA
                       Cell balls
                       Basophilic cytoplasm
Endocervical Adeno CA in situ
       Atypical cells
Columnar morphology
       Feathering (pseudostratified syncytial –like arrangement)
       Rosettes
       DDx
               SSC in situ
               Tubal Metaplasia
                       Has Cilia or terminal bars
Endometrial Adeno CA
       Cell clusters w/ overlapping nuclei
       Irregular chromatin
       Large Nucleoli
       Watery basophilic diathesis
       Type I is assoc. w/ hyper-estrogen
HSIL
       Hyperchromatic
       High N/C ratio
       DDx
               CA in-situ
                       Usually w/ Diathesis & Nucleoli
LSIL
       HPV changes (a must for Dx)
               Koilocytes
Metastatic CA
       Atypical cells
       Usually no diathesis
Mixed Mullerian tumor, Homologous
       Endometrial CA w/
               Leiomyosarcoma or
               Endometrial Stomal tumor
Mucinous cystadeno CA, ovary
       Large cells
       Vacuolated cytoplasm
       Hyperchromasia
       Anisonucleosis
       Large Nucleoli
       Signet Rings
SCC, Keratinizing
       Pleomorphism
       Orangophilia
       Single cells
       Granular diathesis
SCC, Non-keratinizing
       Pleomorphism
       Large Nucleoli
       Diathesis
       Irregular chromatin
       DDx
               SCC in situ
                       No Large Nucleoli
                       No diathesis
                       No irregular chromatin
Small cell CA
       Vertebral-like cellular arrangement
       Fine chromatin
       No large Nucleoli
       Nuclear molding